解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Computational analysis of human adenovirus type 4 (HAdV-E4), a pathogen that is the only HAdV member of species E, provides insights into its zoonotic origin and molecular adaptation. Its genome encodes a domain of the major capsid protein, hexon, from HAdV-B16 recombined into the genome chassis of a simian adenovirus...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.05.014
更新日期:2013-09-01 00:00:00
abstract::The measles virus (MV) phosphoprotein (P) and V proteins block the interferon (IFN) response by impeding phosphorylation of the signal transducer and activator of transcription 1 (STAT1) by the Janus kinase 1 (JAK1). We characterized how STAT1 mutants interact with P and JAK1 phosphorylation. Certain mutants of the li...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.06.019
更新日期:2013-09-01 00:00:00
abstract::The aim of this study was to establish a method that could differentiate antibodies against live and inactivated vaccines of porcine reproductive and respiratory syndrome virus (PRRSV). A blocking ELISA (b-ELISA) was established using the PRRSV non-structural protein, Nsp9, as the antigen and a monoclonal antibody, 2D...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.06.027
更新日期:2013-09-01 00:00:00
abstract::HCV genotype is a major determinant of clinical outcome, and GT1b HCV infection is the most difficult to treat and also the predominant genotype in East Asia and Europe. We developed 1b/JFH-1 inter-genotypic recombinants containing the structural genes (Core, E1, E2), p7 and the 1stTMD of NS2 directly from GT1b clinic...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.04.030
更新日期:2013-08-15 00:00:00
abstract::Altered cytokine profiles and imbalanced frequencies of CD4(+) T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need to be further clarified. Histamine, a biogenic amine with many functions, shows enhancement in HIV-1 infected individuals, which are considered to link with di...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.04.009
更新日期:2013-08-01 00:00:00
abstract::Next generation sequence analyses were used to assess virus-derived small RNA (vsRNA) profiles for Homalodisca coagulata virus-1 (HoCV-1), family Dicistroviridae, and Homalodisca vitripennis reovirus (HoVRV), family Reoviridae, from virus-infected H. vitripennis, the glassy-winged sharpshooter. The vsRNA reads were ma...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.04.005
更新日期:2013-07-20 00:00:00
abstract::The nucleocapsids of many plant viruses are significantly more robust and protective of their RNA contents than those of enveloped animal viruses. In particular, the capsid protein (CP) of the plant virus Cowpea Chlorotic Mottle Virus (CCMV) is of special interest because it has been shown to spontaneously package, wi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.03.001
更新日期:2013-06-20 00:00:00
abstract::Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes. We show that hemagglutination involves selective recognition of the non-human sialic acid N-g...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.02.009
更新日期:2013-05-25 00:00:00
abstract::Traditional virus inoculation of plants involves mechanical rubbing of leaves, whereas in nature viruses like Tomato bushy stunt virus (TBSV) are often infected via the roots. A method was adapted to compare leaf versus root inoculation of Nicotiana benthamiana and tomato with transcripts of wild-type TBSV (wtTBSV), a...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.01.011
更新日期:2013-05-10 00:00:00
abstract::Nonspecific anti-inflammatory drugs have been purported to reduce the burden of severe influenza disease. We demonstrate that, unlike oseltamivir administration, simvastatin administration did not reduce morbidity, mortality, or viral load of mice infected with H1N1 or H5N1 viruses. No added benefit to the efficacy of...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.01.017
更新日期:2013-04-25 00:00:00
abstract::Classical swine fever virus (CSFV) is a positive-sense RNA virus with a high degree of genetic variability among isolates. High diversity is also found in virulence, with strains covering the complete spectrum from avirulent to highly virulent. The underlying genetic determinants are far from being understood. Since R...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.11.020
更新日期:2013-03-30 00:00:00
abstract::Although it is known that Ad5-specific neutralizing antibodies (NAbs) against three major viral capsid components (hexon, penton and fiber) are generated, differences in the frequency and nature of these pre-existing NAbs remain unclear. The results emphasized the contribution of anti-fiber antibodies to Ad5 neutraliz...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.12.014
更新日期:2013-03-15 00:00:00
abstract::We previously showed that reduced infectivity of HIV with incompletely processed capsid-spacer protein 1 (CA-SP1) is rescued by cellular activation or increased expression of HSP90AB1, a member of the cytosolic heat shock protein 90 family. Here we show that HSP90AB1 is present in HIV virions and that HSP90AB1, but no...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.11.005
更新日期:2013-02-05 00:00:00
abstract::Maturation of the arenavirus GP precursor (GPC) involves proteolytic processing by cellular signal peptidase and the proprotein convertase subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P), yielding a tripartite complex comprised of a stable signal peptide (SSP), the receptor-binding GP1, and the fusion-active ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.10.038
更新日期:2013-02-05 00:00:00
abstract::Information about the basic biological properties of human rhinovirus-C (HRV-C) viruses is lacking due to difficulties with culturing these viruses. Our objective was to develop a cell culture system to grow HRV-C. Epithelial cells from human sinuses (HSEC) were differentiated at air-liquid interface (ALI). Differenti...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.11.002
更新日期:2013-02-05 00:00:00
abstract::Foot-and-mouth disease virus (FMDV) VP1 G-H loop contains the major antigenic site. By replacing the sequence upstream of the RGD motif with a FLAG epitope, a marker virus for pathogenesis studies was generated. In cell culture, the recombinant virus containing FLAG (A24-FLAG) exhibited similar plaque phenotypes and g...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.11.001
更新日期:2013-02-05 00:00:00
abstract::The quasispecies structure of nervous necrosis virus (NNV) was determined to investigate an outbreak of viral nervous necrosis disease at a barramundi (Lates calcarifer) hatchery. A traditional epidemiological investigation indicated horizontal transmission of infection between two cohorts of fish. However, variation ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.10.011
更新日期:2013-02-05 00:00:00
abstract::Interleukin 2-inducible T cell kinase (ITK) influences T cell signaling by coordinating actin polymerization and polarization as well as recruitment of kinases and adapter proteins. ITK regulates multiple steps of HIV-1 replication, including virion assembly and release. Fluorescent microscopy was used to examine the ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.11.015
更新日期:2013-02-05 00:00:00
abstract::Recent findings suggested that the SUMO-interacting motifs (SIMs) present in the human TRIM5α (TRIM5α(hu)) protein play an important role in the ability of TRIM5α(hu) to restrict N-MLV. Here we explored the role of SIMs in the ability of rhesus TRIM5α (TRIM5α(rh)) to restrict HIV-1, and found that TRIM5α(rh) SIM mutan...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.09.042
更新日期:2013-01-20 00:00:00
abstract::Despite significant contributions of monocytes to HIV persistence, the genomic basis of HIV-infection of monocytes and its association with plasma viremia remain elusive. To understand HIV interactions with monocytes during disease progression, monocytic transcriptomes from long-term non-progressors (LTNP), HIV+ patie...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.10.026
更新日期:2013-01-20 00:00:00
abstract::The 37K protein of Chinese wheat mosaic virus (CWMV) belongs to the 30K superfamily of plant virus movement proteins. CWMV 37K trans-complemented the cell-to-cell spread of a movement-defective Potato virus X. CWMV 37K fused to enhanced green fluorescent protein localized to plasmodesmata and formed endoplasmic reticu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.10.024
更新日期:2013-01-20 00:00:00
abstract::To accomplish their viral life cycle, lentiviruses such as HIV highjack host proteins, the so-called cellular co-factors of replication. Lens Epithelium-derived Growth factor (LEDGF/p75), a transcriptional co-activator, is a co-factor of HIV-integrase (IN) and is required for the tethering and correct integration of t...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2012.09.033
更新日期:2013-01-05 00:00:00
abstract::Molecular piracy is a biological phenomenon in which one replicon (the pirate) uses the structural proteins encoded by another replicon (the helper) to package its own genome and thus allow its propagation and spread. Such piracy is dependent on a complex web of interactions between the helper and the pirate that occu...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2012.10.028
更新日期:2012-12-20 00:00:00
abstract::A critical feature of highly pathogenic avian influenza viruses (H5N1 and H7N7) is the efficient intracellular cleavage of the hemagglutinin (HA) protein. H7N7 viruses also exist in equine species, and a unique feature of the equine H7N7 HA is the presence of an eleven amino acid insertion directly N-terminal to a tet...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.09.004
更新日期:2012-12-05 00:00:00
abstract::The poxvirus virion contains an inner tubular nucleocapsid structure. The nucleocapsid is apparently labile to conventional electron microscopy fixation procedures and has therefore been largely ignored for decades. Advancements in electron microscopy sample preparation, notably high pressure freezing, better preserve...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.08.019
更新日期:2012-12-05 00:00:00
abstract::We present a case of sexual transmission of HIV-1 predicted to have CXCR4-tropism during male-to-male sexual exposure. Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event. ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.09.010
更新日期:2012-12-05 00:00:00
abstract::A chloroplast-localized papaya methionine sulfoxide reductase B1 (PaMsrB1) interacting with Papaya ringspot virus (PRSV) NIa-Pro was identified using a Sos recruitment two-hybrid system (SRS). SRS analysis of several deletion mutants of PRSV NIa-Pro and PaMsrB1 demonstrated that the C-terminal (residues 133-239) fragm...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.09.007
更新日期:2012-12-05 00:00:00
abstract::Dendrolimus punctatus tetravirus (DpTV) belongs to the genus omegatetravirus of the Alphatetraviridae family. Sequence analysis predicts that DpTV replicase contains a putative helicase domain (Hel). However, the helicase activity in alphatetraviruses has never been formally determined. In this study, we determined th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.08.045
更新日期:2012-11-25 00:00:00
abstract::Flock house virus (FHV) encodes a suppressor protein B2 to overcome antiviral RNA silencing during infection. Biochemical analyses have shown that a homodimer of B2 binds to double-stranded RNA to inhibit dicer-mediated cleavage of dsRNA and incorporation of small interfering RNAs into the RNA-induced silencing comple...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.05.023
更新日期:2012-10-25 00:00:00
abstract::Coronavirus (CoV) envelope (E) protein ion channel activity was determined in channels formed in planar lipid bilayers by peptides representing either the transmembrane domain of severe acute respiratory syndrome CoV (SARS-CoV) E protein, or the full-length E protein. Both of them formed a voltage independent ion cond...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.07.005
更新日期:2012-10-25 00:00:00
abstract::Structure-guided approaches to HIV-1 vaccine design depend on knowledge of the presentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAb b12. Here, we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their b12-bound conformation, ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.06.024
更新日期:2012-10-25 00:00:00
abstract::The complete genomic RNAs of two Korean sacbrood virus (SBV) strains, which infect the honey bee, Apis mellifera, were sequenced. The two sequences (AmSBV-Kor19, AmSBV-Kor21) were distinguished by the presence or absence of a PstI restriction site. These strains comprised of 8784 bp and 8835 bp; contained a single lar...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.06.008
更新日期:2012-10-10 00:00:00
abstract::The mitotic spindle assembly checkpoint (SAC) ensures faithful chromosome segregation during mitosis by censoring kinetochore-microtubule interactions. It is frequently rendered dysfunctional during carcinogenesis causing chromosome missegregation and genomic instability. There are conflicting reports whether the HPV1...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.06.006
更新日期:2012-10-10 00:00:00
abstract::Simian-human immunodeficiency virus encoding both reverse transcriptase (RT) and envelope genes of HIV-1 (RT Env SHIV) is important for evaluating biomedical prevention modalities for HIV/AIDS. We describe virological characterization of a clade B RT Env SHIV following infection of macaques via multiple routes. In viv...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.05.034
更新日期:2012-10-10 00:00:00
abstract::The unordered N-termini of parvovirus capsid proteins (Nt) are translocated through a channel at the icosahedral five-fold axis to serve for virus traffick. Heterologous peptides were genetically inserted at the Nt of MVM to study their functional tolerance to manipulations. Insertion of a 5T4-single-chain antibody at...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.05.025
更新日期:2012-10-10 00:00:00
abstract::Natural antibodies to gp41 inhibit HIV-1 replication through the recognition of two different regions, corresponding to the leucine zipper motif in the HR1 alpha-helix and to another motif within HR2 region, hosting 2F5 and 4E10 epitope. This study aimed at reproducing such protective responses through VLP vaccination...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.05.005
更新日期:2012-09-15 00:00:00
abstract::HIV-1 entry into cells requires the interaction of both HIV-1 envelope proteins and membrane lipids. We investigated the mechanism of neutralization of HIV-1 infection of primary monocyte-derived macrophages (MDM) by a murine monoclonal antibody (mAb) WR321. WR321 specifically binds phosphatidylinositol-4-phosphate an...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.04.017
更新日期:2012-09-01 00:00:00
abstract::Hepatitis A virus infection and growth in cultured cells is protracted, cell-type restricted, and generally not accompanied by the appearance of a cytopathic effect, with the exception of some culture-adapted strains. We demonstrate that the non-cytopathic HAV strain HM175/clone 1 can be induced to exhibit a cytopathi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.04.010
更新日期:2012-08-15 00:00:00
abstract::In this study, we confirmed the autophagy induced by porcine reproductive and respiratory syndrome virus (PRRSV) in permissive cells and investigated the role of autophagy in the replication of PRRSV. We first demonstrated that PRRSV infection significantly results in the increased double-membrane vesicles, the accumu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.03.022
更新日期:2012-08-01 00:00:00
abstract::The envelope (E) protein of dengue virus (DENV) is composed of three domains (EDI, EDII, EDIII) and is the main target of neutralizing antibodies. Many monoclonal antibodies that bind EDIII strongly neutralize DENV. However in vitro studies indicate that anti-EDIII antibodies contribute little to the neutralizing pote...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.03.003
更新日期:2012-07-20 00:00:00